USF2 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant USF2.
|Application ||WB, IHC, IF|
|Other Names||Upstream stimulatory factor 2, Class B basic helix-loop-helix protein 12, bHLHb12, FOS-interacting protein, FIP, Major late transcription factor 2, Upstream transcription factor 2, USF2, BHLHB12|
|Target/Specificity||USF2 (NP_003358, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||USF2 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.
Upstream stimulatory factor 2, a novel FoxA1-interacting protein, is involved in prostate-specific gene expression. Sun Q, et al. Mol Endocrinol, 2009 Dec. PMID 19846536.The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. Landa I, et al. PLoS Genet, 2009 Sep. PMID 19730683.HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells. Wang L, et al. Int J Cancer, 2009 Apr 1. PMID 19089909.Upstream stimulatory factors are involved in the P1 promoter directed transcription of the A beta H-J-J locus. Finotti A, et al. BMC Mol Biol, 2008 Dec 16. PMID 19087304.Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth. Agirre X, et al. Mol Cancer Res, 2008 Dec. PMID 19074828.
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