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VAV1 Antibody (monoclonal) (M04)

Mouse monoclonal antibody raised against a partial recombinant VAV1.

  • WB - VAV1 Antibody (monoclonal) (M04) AT4503a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) .
  • WB - VAV1 Antibody (monoclonal) (M04) AT4503a
    VAV1 monoclonal antibody (M04), clone 3A11 Western Blot analysis of VAV1 expression in Jurkat ( (Cat # AT4503a )
  • IF - VAV1 Antibody (monoclonal) (M04) AT4503a
    Immunofluorescence of monoclonal antibody to VAV1 on HeLa cell. [antibody concentration 10 ug/ml]
  • E - VAV1 Antibody (monoclonal) (M04) AT4503a
    Detection limit for recombinant GST tagged VAV1 is approximately 1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P15498
Other Accession BC013361
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 3A11
Calculated MW 98314 Da
Additional Information
Gene ID 7409
Other Names Proto-oncogene vav, VAV1, VAV
Target/Specificity VAV1 (AAH13361, 681 a.a. ~ 790 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsVAV1 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.


Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Cooperative interactions at the SLP-76 complex are critical for actin polymerization. Barda-Saad M, et al. EMBO J, 2010 Jul 21. PMID 20562827.New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase. Kim HS, et al. Immunity, 2010 Feb 26. PMID 20189481.Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Yu B, et al. Cell, 2010 Jan 22. PMID 20141838.

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$ 315.00
Cat# AT4503a
(40 western blots)
Availability: 7-10 days
Bulk Size
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