VPREB3 Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a partial recombinant VPREB3.
|Calculated MW||13710 Da|
|Other Names||Pre-B lymphocyte protein 3, N27C7-2, Protein VPreB3, VPREB3|
|Target/Specificity||VPREB3 (NP_037510, 24 a.a. ~ 123 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||VPREB3 Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene is the human homolog of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-cell differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. This protein associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of the protein is not known, but it may contribute to mu chain transport in pre-B cells.
Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript. Rangel R, et al. J Biol Chem, 2005 May 6. PMID 15757909.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.A genome annotation-driven approach to cloning the human ORFeome. Collins JE, et al. Genome Biol, 2004. PMID 15461802.Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells. Rosnet O, et al. J Biol Chem, 2004 Mar 12. PMID 14670953.
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