VRK2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant VRK2.
|Application ||WB, IF, E|
|Calculated MW||58141 Da|
|Other Names||Serine/threonine-protein kinase VRK2, Vaccinia-related kinase 2, VRK2|
|Target/Specificity||VRK2 (AAH27854, 260 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||VRK2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. Multiple alternatively spliced transcript variants have been found for this gene.
Common variants conferring risk of schizophrenia. Stefansson H, et al. Nature, 2009 Aug 6. PMID 19571808.Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. Sanz-Garc?a M, et al. Mol Cell Proteomics, 2008 Nov. PMID 18617507.The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53. Valbuena A, et al. PLoS One, 2008 Jul 9. PMID 18612383.Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. Blanco S, et al. PLoS One, 2008 Feb 20. PMID 18286207.Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. Blanco S, et al. Mol Cell Biol, 2007 Oct. PMID 17709393.
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