VSNL1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant VSNL1.
|Application ||WB, E|
|Calculated MW||22142 Da|
|Other Names||Visinin-like protein 1, VILIP, VLP-1, Hippocalcin-like protein 3, HLP3, VSNL1, VISL1|
|Target/Specificity||VSNL1 (AAH22012, 1 a.a. ~ 191 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||VSNL1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. Xu Y, et al. Schizophr Res, 2010 Jun. PMID 20347265.Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart. Buttgereit J, et al. Regul Pept, 2010 Apr 9. PMID 20079378.Promoter regulation of the visinin-like subfamily of neuronal calcium sensor proteins by nuclear respiratory factor-1. Fu J, et al. J Biol Chem, 2009 Oct 2. PMID 19674972.Regulatory elements and functional implication for the formation of dimeric visinin-like protein-1. Chen KC, et al. J Pept Sci, 2009 Feb. PMID 19065602.Neuronal Ca2+ sensor VILIP-1 leads to the upregulation of functional alpha4beta2 nicotinic acetylcholine receptors in hippocampal neurons. Zhao CJ, et al. Mol Cell Neurosci, 2009 Feb. PMID 19063970.
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