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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   WISP2 Antibody (monoclonal) (M09)   

WISP2 Antibody (monoclonal) (M09)

Mouse monoclonal antibody raised against a full length recombinant WISP2.

  • WB - WISP2 Antibody (monoclonal) (M09) AT4540a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (50.71 KDa) .
  • WB - WISP2 Antibody (monoclonal) (M09) AT4540a
    Western Blot analysis of WISP2 expression in transfected 293T cell line by WISP2 monoclonal antibody (M09), clone 3D10.

    Lane 1: WISP2 transfected lysate(26.8 KDa).
    Lane 2: Non-transfected lysate.
  • IP - WISP2 Antibody (monoclonal) (M09) AT4540a
    Immunoprecipitation of WISP2 transfected lysate using anti-WISP2 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with WISP2 MaxPab rabbit polyclonal antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O76076
Other Accession BC017782
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 3D10
Calculated MW 26825 Da
Additional Information
Gene ID 8839
Other Names WNT1-inducible-signaling pathway protein 2, WISP-2, CCN family member 5, Connective tissue growth factor-like protein, CTGF-L, Connective tissue growth factor-related protein 58, WISP2, CCN5, CT58, CTGFL
Target/Specificity WISP2 (AAH17782.1, 24 a.a. ~ 250 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsWISP2 Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.


Differential expression of CCN1/CYR61, CCN3/NOV, CCN4/WISP1, and CCN5/WISP2 in neurofibromatosis type 1 tumorigenesis. Pasmant E, et al. J Neuropathol Exp Neurol, 2010 Jan. PMID 20010302.High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Yerges LM, et al. J Bone Miner Res, 2009 Dec. PMID 19453261.CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells. Banerjee S, et al. Cancer Res, 2008 Sep 15. PMID 18794149.Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2. Dhar G, et al. Cancer Res, 2008 Jun 15. PMID 18559502.Role of WISP-2/CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast cancer cells. Fritah A, et al. Mol Cell Biol, 2008 Feb. PMID 18070926.

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$ 315.00
Cat# AT4540a
(40 western blots)
Availability: 7-10 days
Bulk Size
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