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>   home   >   Products   >   Primary Antibodies   >   WRN Antibody (monoclonal) (M09)   

WRN Antibody (monoclonal) (M09)

Mouse monoclonal antibody raised against a partial recombinant WRN.

  • WB - WRN Antibody (monoclonal) (M09) AT4544a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.95 KDa) .
  • WB - WRN Antibody (monoclonal) (M09) AT4544a
    WRN monoclonal antibody (M09), clone 3C11 Western Blot analysis of WRN expression in Hela S3 NE ( (Cat # AT4544a )
  • IF - WRN Antibody (monoclonal) (M09) AT4544a
    Immunofluorescence of monoclonal antibody to WRN on HeLa cell. [antibody concentration 10 ug/ml]
  • E - WRN Antibody (monoclonal) (M09) AT4544a
    Detection limit for recombinant GST tagged WRN is approximately 0.3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14191
Other Accession NM_000553
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 3C11
Calculated MW 162461 Da
Additional Information
Gene ID 7486
Other Names Werner syndrome ATP-dependent helicase, DNA helicase, RecQ-like type 3, RecQ3, Exonuclease WRN, 31--, RecQ protein-like 2, WRN, RECQ3, RECQL2
Target/Specificity WRN (NP_000544, 1322 a.a. ~ 1432 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsWRN Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.


Lack of association of the WRN C1367T polymorphism with senile cataract in the Israeli population. Ehrenberg M, et al. Mol Vis, 2010 Aug 28. PMID 20808731.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Variation within DNA repair pathway genes and risk of multiple sclerosis. Briggs FB, et al. Am J Epidemiol, 2010 Jul 15. PMID 20522537.Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity. Perry JJ, et al. J Biol Chem, 2010 Aug 13. PMID 20516064.Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2010 May 28. PMID 20508983.

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$ 315.00
Cat# AT4544a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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