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WWP1 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant WWP1.

  • WB - WWP1 Antibody (monoclonal) (M01) AT4546a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.73 KDa) .
  • WB - WWP1 Antibody (monoclonal) (M01) AT4546a
    Western Blot analysis of WWP1 expression in transfected 293T cell line by WWP1 monoclonal antibody (M01), clone 1A7.

    Lane 1: WWP1 transfected lysate(105.2 KDa).
    Lane 2: Non-transfected lysate.
  • IHC - WWP1 Antibody (monoclonal) (M01) AT4546a
    Immunoperoxidase of monoclonal antibody to WWP1 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml]
  • IF - WWP1 Antibody (monoclonal) (M01) AT4546a
    Immunofluorescence of monoclonal antibody to WWP1 on A-431 cell. [antibody concentration 10 ug/ml]
  • IP - WWP1 Antibody (monoclonal) (M01) AT4546a
    Immunoprecipitation of WWP1 transfected lysate using anti-WWP1 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with WWP1 MaxPab rabbit polyclonal antibody.
  • E - WWP1 Antibody (monoclonal) (M01) AT4546a
    Detection limit for recombinant GST tagged WWP1 is 0.03 ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H0M0
Other Accession NM_007013
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 1A7
Calculated MW 105202 Da
Additional Information
Gene ID 11059
Other Names NEDD4-like E3 ubiquitin-protein ligase WWP1, 632-, Atrophin-1-interacting protein 5, AIP5, TGIF-interacting ubiquitin ligase 1, Tiul1, WW domain-containing protein 1, WWP1
Target/Specificity WWP1 (NP_008944, 152 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsWWP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.


1.Knockdown of WWP1 inhibits growth and induces apoptosis in hepatoma carcinoma cells through the activation of caspase3 and p53.Cheng Q, Cao X, Yuan F, Li G, Tong TBiochem Biophys Res Commun. 2014 May 1. pii: S0006-291X(14)00780-3. doi: 10.1016/j.bbrc.2014.04.117.2.WWP1 delays cellular senescence by promoting p27Kip1 degradation in human diploid fibroblasts.Cao X, Xue L, Han L, Ma L, Chen T, Tong T.J Biol Chem. 2011 Jul 27. [Epub ahead of print]3.The E3 ubiquitin ligase WWP1 regulates ?GNp63-dependent transcription through Lys63 linkages.Peschiaroli A, Scialpi F, Bernassola F, Sherbini el SE, Melino G.Biochem Biophys Res Commun. 2010 Nov 12;402(2):425-30. Epub 2010 Oct 15.4.Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5.Edwards TL, Clowes VE, Tsang HT, Connell JW, Sanderson CM, Luzio JP, Reid E.Biochem J. 2009 Sep 14;423(1):31-9.

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$ 315.00
Cat# AT4546a
(40 western blots)
Availability: 7-10 days
Bulk Size
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