|Application ||WB, E|
|Calculated MW||105953 Da|
|Other Names||DNA repair protein complementing XP-C cells, Xeroderma pigmentosum group C-complementing protein, p125, XPC, XPCC|
|Target/Specificity||XPC (NP_004619, 141 a.a. ~ 250 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||XPC Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer. Palli D, et al. Mutagenesis, 2010 Sep 3. PMID 20817763.Polymorphism in xeroderma pigmentosum complementation group C codon 939 and aflatoxin B1-related hepatocellular carcinoma in the Guangxi population. Long XD, et al. Hepatology, 2010 Jun 16. PMID 20658464.Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma. Figl A, et al. Mutat Res, 2010 Sep 30. PMID 20601096.XPC genetic polymorphisms correlate with the response to imatinib treatment in patients with chronic phase chronic myeloid leukemia. Guillem VM, et al. Am J Hematol, 2010 Jul. PMID 20575039.XPC gene intron 11 C/A polymorphism is a predictive biomarker for the sensitivity to NP chemotherapy in patients with non-small cell lung cancer. Zhu LB, et al. Anticancer Drugs, 2010 Aug. PMID 20571354.
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