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YWHAH Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant YWHAH.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q04917 |
| Other Accession | BC003047 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 6A12 |
| Calculated MW | 28219 Da |
| Gene ID | 7533 |
|---|---|
| Other Names | 14-3-3 protein eta, Protein AS1, YWHAH, YWHA1 |
| Target/Specificity | YWHAH (AAH03047, 71 a.a. ~ 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | YWHAH Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder.
References
The expression of seven 14-3-3 isoforms in human meningioma. Liu Y, et al. Brain Res, 2010 Jun 8. PMID 20388496.Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin. Margariti A, et al. Circ Res, 2010 Apr 16. PMID 20224040.Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets. Mangin PH, et al. J Thromb Haemost, 2009 Sep. PMID 19558434.Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. Brummer T, et al. EMBO J, 2008 Sep 3. PMID 19172738.
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