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ZAK Antibody (monoclonal) (M02)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT4567a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ZAK Antibody (monoclonal) (M02) - Product info | |
| Application | IF
|
| Primary Accession | - |
| Reactivity | Human |
| Isotype | IgG1 Kappa |
| Clone Names | 3D11 |
ZAK Antibody (monoclonal) (M02) - Additional info | |
| Other Names AZK, MLK7, MLT, MLTK, MRK, mlklaksterile alpha motif and leucine zipper containing kinase AZK | |
| Target/Specificity ZAK (AAH01401, 1 a.a. ~ 456 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ZAK Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ZAK Antibody (monoclonal) (M02) - Application data
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Immunofluorescence of to ZAK ( Cat# AT4567a ) on HeLa cell .
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Detection limit for recombinant GST tagged ZAK is approximately 0.3ng/ml as a capture antibody.
ZAK Antibody (monoclonal) (M02) - Related products
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BACKGROUND
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
REFERENCES
Mapping of phosphorylation sites in human MSK1 activated by a novel interaction with MRK-beta. Wang W, et al. Electrophoresis, 2010 Apr. PMID 20408143.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP-1-dependent manner. Yang JJ, et al. Cancer Sci, 2010 Jun. PMID 20331627.ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression. Jandhyala DM, et al. Cell Microbiol, 2008 Jul. PMID 18331592.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
