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ZFP36L1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant ZFP36L1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q07352 |
| Other Accession | NM_004926 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1A3 |
| Calculated MW | 36314 Da |
| Gene ID | 677 |
|---|---|
| Other Names | Zinc finger protein 36, C3H1 type-like 1, Butyrate response factor 1, EGF-response factor 1, ERF-1, Protein TIS11B, ZFP36L1, BERG36, BRF1, ERF1, RNF162B, TIS11B |
| Target/Specificity | ZFP36L1 (NP_004917, 1 a.a. ~ 108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ZFP36L1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors.
References
Multiple common variants for celiac disease influencing immune gene expression. Dubois PC, et al. Nat Genet, 2010 Apr. PMID 20190752.ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. Hacker C, et al. Growth Factors, 2010 Jun. PMID 20166898.Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: impact on vascular endothelial growth factor expression in hypoxia. Sinha S, et al. J Biol Chem, 2009 Nov 20. PMID 19801654.Structural insights into eRF3 and stop codon recognition by eRF1. Cheng Z, et al. Genes Dev, 2009 May 1. PMID 19417105.Involvement of Tis11b, an AU-rich binding protein, in induction of apoptosis by rituximab in B cell chronic lymphocytic leukemia cells. Baou M, et al. Leukemia, 2009 May. PMID 19092855.
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