ZNFN1A3 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant ZNFN1A3.
|Application ||IF, E|
|Calculated MW||58023 Da|
|Other Names||Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3|
|Target/Specificity||ZNFN1A3 (AAH32707, 1 a.a. ~ 509 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ZNFN1A3 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.
Analysis of Ikaros family splicing variants in human hematopoietic lineages. Matuli? M, et al. Coll Antropol, 2010 Mar. PMID 20432734.Differential aiolos expression in human hematopoietic subpopulations. Billot K, et al. Leuk Res, 2010 Mar. PMID 19540588.Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. Hirschfield GM, et al. N Engl J Med, 2009 Jun 11. PMID 19458352.Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. Mavaddat N, et al. Cancer Epidemiol Biomarkers Prev, 2009 Jan. PMID 19124506.Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. Vieira AR, et al. Genet Med, 2008 Sep. PMID 18978678.
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