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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ZYX Antibody (monoclonal) (M01)   

ZYX Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant ZYX.

  • WB - ZYX Antibody (monoclonal) (M01) AT4653a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (88.66 KDa) .
  • WB - ZYX Antibody (monoclonal) (M01) AT4653a
    Western Blot analysis of ZYX expression in transfected 293T cell line by ZYX monoclonal antibody (M01), clone 2C10-4A7.

    Lane 1: ZYX transfected lysate(61.3 KDa).
    Lane 2: Non-transfected lysate.
  • IF - ZYX Antibody (monoclonal) (M01) AT4653a
    Immunofluorescence of monoclonal antibody to ZYX on HeLa cell . [antibody concentration 10 ug/ml]
  • IP - ZYX Antibody (monoclonal) (M01) AT4653a
    Immunoprecipitation of ZYX transfected lysate using anti-ZYX monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with ZYX MaxPab rabbit polyclonal antibody.
  • E - ZYX Antibody (monoclonal) (M01) AT4653a
    Detection limit for recombinant GST tagged ZYX is 1 ng/ml as a capture antibody.
  • WB - ZYX Antibody (monoclonal) (M01) AT4653a
    Western blot analysis of ZYX over-expressed 293 cell line, cotransfected with ZYX Validated Chimera RNAi ( (Cat # AT4653a )
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15942
Other Accession BC008743
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 kappa
Clone Names 2C10-4A7
Calculated MW 61277 Da
Additional Information
Gene ID 7791
Other Names Zyxin, Zyxin-2, ZYX
Target/Specificity ZYX (AAH08743, 1 a.a. ~ 572 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsZYX Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.


1.Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner.Hirata H, Tatsumi H, Sokabe M.J Cell Sci. 2008 Sep 1;121(Pt 17):2795-804. Epub 2008 Aug 5.

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$ 315.00
Cat# AT4653a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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