ZYX Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant ZYX.
|Application ||WB, IF, IP, E|
|Calculated MW||61277 Da|
|Other Names||Zyxin, Zyxin-2, ZYX|
|Target/Specificity||ZYX (AAH08743, 1 a.a. ~ 572 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ZYX Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
1.Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner.Hirata H, Tatsumi H, Sokabe M.J Cell Sci. 2008 Sep 1;121(Pt 17):2795-804. Epub 2008 Aug 5.
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