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>   home   >   Products   >   Primary Antibodies   >   POLR3E monoclonal antibody (M03)   

POLR3E monoclonal antibody (M03)

Purified Mouse Monoclonal Antibody (Mab)

  • WB - POLR3E monoclonal antibody (M03) AT4663a
    Western Blot detection against Immunogen (99 KDa)
  • WB - POLR3E monoclonal antibody (M03) AT4663a
    POLR3E monoclonal antibody (M03), clone 4F4. Western Blot analysis of POLR3E expression in U-2 OS
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NVU0
Other Accession BC000285
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 4F4
Calculated MW 79898 Da
Additional Information
Gene ID 101060521;55718
Other Names DNA-directed RNA polymerase III subunit RPC5, RNA polymerase III subunit C5, DNA-directed RNA polymerase III 80 kDa polypeptide, POLR3E, KIAA1452
Target/Specificity POLR3E (AAH00285, 1 a.a. ~ 666 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format In 1x PBS, pH 7.4
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsPOLR3E monoclonal antibody (M03) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).


Hu P.,et al.Mol. Cell. Biol. 22:8044-8055(2002).
Nagase T.,et al.DNA Res. 7:143-150(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Matsuoka S.,et al.Science 316:1160-1166(2007).

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$ 315.00
Cat# AT4663a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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