|Application ||IHC, ICC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||95568 Da|
|Application & Usage||This anti-peptide antibody preparation was validated by immunohistochemistry (at a concentration of 1 µg/ml) using fluorescein-labeled goat anti-chicken IgY (1:500 dilution) as the secondary reagent.|
|Other Names||Metabotropic glutamate receptor 2, mGluR2, GRM2, GPRC1B, MGLUR2|
|Format||Mixture of IgY fraction (10 mg/ml) and affinity-purified antibodies (50 ug/ml) in Phosphate-buffered (10 mM) isotonic (0.9%, w/v) saline (PBS, pH 7.2) with sodium azide (0.02%, w/v).|
|Reconstitution & Storage||-20°C|
|Precautions||Glutamate Receptor (Metabotropic) Type 2 (mGluR2) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite|
|Tissue Location||Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.|
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