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Purified Chicken Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC |
|---|---|
| Primary Accession | P02686 |
| Reactivity | Human, Mouse, Rat |
| Host | Chicken |
| Calculated MW | 33117 Da |
| Gene ID | 4155 |
|---|---|
| Application & Usage | Immunohistochemistry (at a concentration of 3 µg/ml) using fluorescein-labeled goat anti-chicken IgY (1:500 dilution) as the secondary reagent. |
| Other Names | Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein, MBP |
| Format | Mixture of IgY fraction (10 mg/ml) and affinity-purified antibodies (50 ug/ml) in Phosphate-buffered (10 mM) isotonic (0.9%, w/v) saline (PBS, pH 7.2) with sodium azide (0.02%, w/v). |
| Reconstitution & Storage | -20°C |
| Background Descriptions | |
| Precautions | Myelin Basic Protein (MBP) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MBP |
|---|---|
| Function | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. |
| Cellular Location | Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin |
| Tissue Location | MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system |
Research Areas
Citations (0)
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info@abgent.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 335.00
Cat# AVS10017
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