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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Prion Protein Antibody   

Prion Protein Antibody

Purified Chicken Polyclonal Antibody

  • IF - Prion Protein Antibody AVS10027
    Prion Protein Antibody

    Cultured fibroblasts cells transiently transfected with a plasmid containing the prion protein cDNA.

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04156
Reactivity Human, Mouse, Rat
Host Chicken
Calculated MW 27661 Da
Additional Information
Gene ID 5621
Other Names Major prion protein, PrP, ASCR, PrP27-30, PrP33-35C, CD230, PRNP, ALTPRP, PRIP, PRP
Format Mixture of IgY fraction (10 mg/ml) and affinity-purified antibodies (50 ug/ml)
Reconstitution & Storage -20°C
Background Descriptions
PrecautionsPrion Protein Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of CU(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis
Research Areas
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$ 200.00
Cat# AVS10027
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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