|Application ||IHC, ICC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||127179 Da|
|Application & Usage||Immunohistochemistry (at a concentration of 100 ug/ml) using HRP-labeled goat anti-chicken IgY (1:1000 dilution) as the secondary reagent. Please note that these dilutions are meant to serve as starting points, and that optimal dilutions may vary|
|Other Names||Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11b, ITGAM, CD11B, CR3A|
|Format||Phosphate-buffered (10 mM) isotonic saline (0.9%, w.v) with sodium azide (0.02%, w/v) added as a preservative.|
|Reconstitution & Storage||-20°C|
|Precautions||Integrin alpha-M (CD11b, MAC-1, OX-42 Antigen) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein|
|Tissue Location||Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407).|
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