|Calculated MW||H=25 KDa|
|Antigen Region||2-28 aa|
|Other Names||RAB32; Ras-related protein Rab-32|
|Target/Specificity||This RAB32 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-28 amino acids from the N-terminal region of human RAB32.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAB32 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.|
|Cellular Location||Mitochondrion. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side Note=Recruited to phagosomes containing S.aureus or M.tuberculosis|
|Tissue Location||Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Small GTP-binding proteins of the RAB family, such as RAB32, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).
Hirota, Y., et al. Cell. Mol. Life Sci. 66(17):2913-2932(2009)
Shibata, D., et al. Int. J. Cancer 119(4):801-806(2006)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Alto, N.M., et al. J. Cell Biol. 158(4):659-668(2002)
Bao, X., et al. Eur. J. Biochem. 269(1):259-271(2002)
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