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MESDC2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - MESDC2 Antibody (C-term) AW5086-U400
    Western blot analysis of lysates from mouse NIH/3T3,K562 cell line (from left to right), using MESDC2 Antibody (C-term)(Cat. #AW5086). AW5086 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
  • IHC-P - MESDC2 Antibody (C-term) AW5086-U400
    MESDC2 Antibody (C-term)(Cat. #AW5086)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MESDC2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • IF - MESDC2 Antibody (C-term) AW5086-U400
    Confocal immunofluorescent analysis of MESDC2 Antibody (C-term)(Cat#AW5086) with 293 cell followed by Alexa Fluor? 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q14696
Other Accession NP_055969.1
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Calculated MW H=26;M=25;Rat=25 KDa
Additional Information
Gene ID 23184
Antigen Region 206-234 aa
Other Names MESDC2; KIAA0081; MESD; LDLR chaperone MESD; Mesoderm development candidate 2; Mesoderm development protein; Renal carcinoma antigen NY-REN-61
Dilution WB~~1:1000
IHC-P~~1:10~50
IF~~1:10~50
Target/Specificity This MESDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-234 amino acids from the C-terminal region of human MESDC2.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMESDC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MESDC2
Synonyms KIAA0081, MESD
Function Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
Cellular Location Endoplasmic reticulum
Research Areas
Citations (0)

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Background

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.

References

Murrills, R.J., et al. J. Cell. Biochem. 108(5):1066-1075(2009)
Li, Y., et al. FEBS Lett. 580(22):5423-5428(2006)
Veltman, I.M., et al. Hum. Mol. Genet. 14(14):1955-1963(2005)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Hsieh, J.C., et al. Cell 112(3):355-367(2003)

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$ 325.00
$ 110.00
Cat# AW5086-U400
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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