|Application ||WB, IHC-P, IF|
|Other Accession||Q62348, P97891, Q08DM8, NP_004613.1|
|Predicted||Mouse, Hamster, Bovine|
|Calculated MW||H=26;M=26 KDa|
|Antigen Region||109-138 aa|
|Other Names||TSN; Translin; Component 3 of promoter of RISC|
|Target/Specificity||This TSN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human TSN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TSN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|
|Cellular Location||Cytoplasm. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.
Chiaruttini, C., et al. Proc. Natl. Acad. Sci. U.S.A. 106(38):16481-16486(2009)
Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :
Sengupta, K., et al. Biochemistry 45(3):861-870(2006)
Kaluzhny, D., et al. J. Biomol. Struct. Dyn. 23(3):257-265(2005)
Gupta, G.D., et al. FEBS Lett. 579(14):3141-3146(2005)
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