|Application ||WB, IF|
|Calculated MW||H=47;M=46 KDa|
|Antigen Region||31-59 aa|
|Other Names||CRTAP; CASP; Cartilage-associated protein|
|Target/Specificity||This CRTAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-59 amino acids from the N-terminal region of human CRTAP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CRTAP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Found in articular chondrocytes. Expressed in a variety of tissues|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass.
Morello, R., et al. Curr Osteoporos Rep 8(2):77-83(2010)
Li, G.H., et al. Osteoporos Int 21(6):1009-1020(2010)
Fratzl-Zelman, N., et al. Bone 46(3):820-826(2010)
Chang, W., et al. Hum. Mol. Genet. 19(2):223-234(2010)
Marini, J.C., et al. Cell Tissue Res. 339(1):59-70(2010)
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