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ZRSR2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB |
|---|---|
| Primary Accession | Q15696 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=58 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | Human |
| Gene ID | 8233 |
|---|---|
| Antigen Region | 453-482 aa |
| Other Names | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2;U2AF1-RS2; U2AF1L2; U2AF1RS2; URP; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; Renal carcinoma antigen NY-REN-20; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; U2(RNU2) small nuclear RNA auxiliary factor 1-like 2; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; U2AF35-related protein |
| Dilution | WB~~1:1000 IHC-P~~1:25 |
| Target/Specificity | This ZRSR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-482 amino acids from the C-terminal region of human ZRSR2. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZRSR2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZRSR2 |
|---|---|
| Synonyms | U2AF1-RS2, U2AF1L2, U2AF1RS2, URP |
| Function | Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. |
| Cellular Location | Nucleus. |
| Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Pre-mRNA-binding protein required for splicing of both U2-and U12-type introns. Selectively interacts with the 3'-splice site of U2-and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.
References
Kitagawa K., et al. Genomics 30:257-263(1995).
Ross M.T., et al. Nature 434:325-337(2005).
Tronchere H., et al. Nature 388:397-400(1997).
Scanlan M.J., et al. Int. J. Cancer 83:456-464(1999).
Will C.L., et al. RNA 10:929-941(2004).
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