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HUMAN-SHB(Y268) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - HUMAN-SHB(Y268) Antibody AW5136-U400
    Western blot analysis of lysates from HepG2,Jurkat,K562 cell line (from left to right), using Phospho-HUMAN-SHB(Y268).ctrl(Cat. #AW5136). AW5136 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
  • FC - HUMAN-SHB(Y268) Antibody AW5136-U400
    Flow cytometric analysis of HepG2 cells using Phospho-HUMAN-SHB(Y268). ctrl(green, Cat#AW5136) compared to an isotype control of rabbit IgG(blue). AW5136 was diluted at 1:25 dilution. An Alexa Fluor® 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB
Primary Accession Q15464
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality polyclonal
Calculated MW H=55,31;M=55 KDa
Additional Information
Gene ID 6461
Antigen Region 250-290 aa
Other Names SH2 domain-containing adapter protein B, SHB
Dilution WB~~1:1000
FC~~1:25
Target/Specificity This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 250-290 amino acids from human.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHUMAN-SHB(Y268) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SHB
Function Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

References

Welsh M.,et al.Oncogene 9:19-27(1994).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Karlsson T.,et al.Oncogene 10:1475-1483(1995).
Karlsson T.,et al.Oncogene 13:955-961(1996).

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$ 325.00
$ 110.00
Cat# AW5136-U400
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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