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HMGCS2 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB |
|---|---|
| Primary Accession | P54868 |
| Reactivity | Human, Rat |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=57,52,50;M=57;Rat=57 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 3158 |
|---|---|
| Antigen Region | 478-508 aa |
| Other Names | HMGCS2; Hydroxymethylglutaryl-CoA synthase, mitochondrial; 3-hydroxy-3-methylglutaryl coenzyme A synthase |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Target/Specificity | This HMGCS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 478-508 amino acids from the C-terminal region of human HMGCS2. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HMGCS2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HMGCS2 |
|---|---|
| Function | Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. |
| Cellular Location | Mitochondrion {ECO:0000250|UniProtKB:P22791}. |
| Tissue Location | Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas Very low expression in heart and skeletal muscle (PubMed:7893153, PubMed:21952825, PubMed:16940161). Not detected in brain (PubMed:21952825). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
HMGCS2 belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting.
References
Lu,Y., et.al., J. Lipid Res. 49 (12), 2582-2589 (2008)
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