|Other Accession||O70456, Q0VC36, NP_006133.1|
|Calculated MW||H=28,24;M=28 KDa|
|Antigen Region||120-149 aa|
|Other Names||SFN; HME1; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin|
|Target/Specificity||This SFN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the Central region of human SFN.|
|Precautions||SFN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.|
|Cellular Location||Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway|
|Tissue Location||Present mainly in tissues enriched in stratified squamous keratinizing epithelium|
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Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
Ren, H.Z., et al. Dig. Dis. Sci. 55(9):2552-2560(2010)
Liu, Y., et al. Brain Res. 1336, 98-102 (2010) :
Pei, H.P., et al. Zhonghua Wei Chang Wai Ke Za Zhi 13(3):213-215(2010)
Syrjanen, S., et al. Am. J. Clin. Pathol. 133(2):232-240(2010)
Zurita, M., et al. BMC Cancer 10, 217 (2010) :
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