|Other Accession||Q8K0H5, NP_006275.1|
|Calculated MW||H=22;M=22 KDa|
|Antigen Region||121-150 aa|
|Other Names||TAF10; TAF2A; TAF2H; TAFII30; Transcription initiation factor TFIID subunit 10; STAF28; Transcription initiation factor TFIID 30 kDa subunit|
|Target/Specificity||This TAF10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-150 amino acids from the Central region of human TAF10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAF10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||TAF2A, TAF2H, TAFII30|
|Function||TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.|
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Provided below are standard protocols that you may find useful for product applications.
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs.
Egloff, S., et al. J. Biol. Chem. 285(27):20564-20569(2010)
Ma, Y., et al. J. Biol. Chem. 285(13):9813-9822(2010)
Zhao, Y., et al. Mol. Cell 29(1):92-101(2008)
Hao, H., et al. Oncogene 26(57):7872-7884(2007)
Couture, J.F., et al. Nat. Struct. Mol. Biol. 13(2):140-146(2006)
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