|Application ||FC, WB|
|Other Accession||O35182, NP_005576.3|
|Calculated MW||H=53,26,35;M=54 KDa|
|Antigen Region||358-386 aa|
|Other Names||SMAD6; MADH6; Mothers against decapentaplegic homolog 6; SMAD family member 6|
|Target/Specificity||This SMAD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-386 amino acids from the Central region of human SMAD6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SMAD6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.|
|Tissue Location||Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue|
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Provided below are standard protocols that you may find useful for product applications.
SMAD6 belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling.
Tseng, Z.H., et al. Heart Rhythm 6(12):1745-1750(2009)
Shintani, M., et al. J. Med. Genet. 46(5):331-337(2009)
Yu, H., et al. Acta Derm. Venereol. 89(4):351-356(2009)
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