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ITPA Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - ITPA Antibody (N-term) AW5332-U400
    Western blot analysis of lysates from A375,Hela,HepG2 cell line,mouse brain,rat liver tissue lysate(from left to right), using ITPA Antibody (N-term)(Cat. #AW5332). AW5332 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BY32
Other Accession Q2NLA8, D3ZW55, Q9D892, F1NLH9, Q2KIC5
Reactivity Human, Mouse, Rat
Predicted Bovine, Chicken, Xenopus
Host Rabbit
Clonality Polyclonal
Calculated MW H=21,20;M=22;Rat=22 KDa
Additional Information
Gene ID 3704
Antigen Region 24-51 aa
Other Names ITPA; C20orf37; Inosine triphosphate pyrophosphatase; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; Putative oncogene protein hlc14-06-p
Dilution WB~~1:1000
Target/Specificity This ITPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human ITPA.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsITPA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITPA {ECO:0000255|HAMAP-Rule:MF_03148}
Synonyms C20orf37
Function Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Cellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832}
Tissue Location Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland
Citations (0)

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ITPA hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. The encoded protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency. Two transcript variants encoding two different isoforms have been found for this gene.


Fellay, J., et al. Nature 464(7287):405-408(2010)
Herting, G., et al. Biochim. Biophys. Acta 1802(2):269-274(2010)
Kudo, M., et al. Drug Metab. Pharmacokinet. 24(6):557-564(2009)

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$ 325.00
$ 110.00
Cat# AW5332-U400
(40 western blots)
Availability: In Stock
Bulk Size
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