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EPOR Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - EPOR Antibody (C-term) AW5363-U400
    All lanes : Anti-EPOR Antibody (C-term)(AW5363) at 1/1000 dilution Lane 1: human kidney lysates Lane 2: HL-60 whole cell lysates Lane 3: Jurkat whole cell lysates Lane 4: K562 whole cell lysates Lane 5: HepG2 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 62 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • FC - EPOR Antibody (C-term) AW5363-U400
    Flow cytometric analysis of K562 cells using EPOR Antibody (C-term)(green, Cat#AW5363) compared to an isotype control of rabbit IgG(blue). AW5363 was diluted at 1:25 dilution. An Alexa Fluor® 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC
Primary Accession P19235
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW H=55 KDa
Additional Information
Gene ID 2057
Antigen Region 470-504 aa
Other Names Erythropoietin receptor, EPO-R, EPOR
Dilution WB~~1:1000
FC~~1:25
Target/Specificity This EPOR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 470-504 amino acids from the C-terminal region of human EPOR.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEPOR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPOR
Function Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early- stage erythroid progenitor cells
Research Areas
Citations (0)

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Background

Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.

References

Winkelmann J.C.,et al.Blood 76:24-30(1990).
Jones S.S.,et al.Blood 76:31-35(1990).
Noguchi C.T.,et al.Blood 78:2548-2556(1991).
Ehrenman K.,et al.Exp. Hematol. 19:973-977(1991).
Nakamura Y.,et al.Science 257:1138-1141(1992).

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$ 325.00
$ 110.00
Cat# AW5363-U400
Size:
Quantity:
(40 western blots)
Availability: In Stock
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