|Application ||IHC-P, WB, IF|
|Other Accession||P70124, NP_002630.2|
|Calculated MW||H=42,26;M=42;Rat=42 KDa|
|Antigen Region||94-123 aa|
|Other Names||SERPINB5; PI5; Serpin B5; Maspin; Peptidase inhibitor 5|
|Target/Specificity||This Maspin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-123 amino acids from the Central region of human Maspin.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Maspin Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Normal mammary epithelial cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SERPINB5 is a tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Kim, J., et al. Tumour Biol. 31(5):471-476(2010)
Juengel, E., et al. World J Urol 28(4):465-471(2010)
Besgen, P., et al. J. Immunol. 184(9):5392-5402(2010)
Fung, C.L., et al. Histopathology 56(3):319-330(2010)
Adim, S.B., et al. World J Surg Oncol 8, 22 (2010) :
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