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CTDSP1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9GZU7 |
| Other Accession | P58466 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=29;M=29 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 58190 |
|---|---|
| Antigen Region | 96-130 aa |
| Other Names | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, Nuclear LIM interactor-interacting factor 3, NLI-IF, NLI-interacting factor 3, Small C-terminal domain phosphatase 1, SCP1, Small CTD phosphatase 1, CTDSP1, NIF3, NLIIF, SCP1 |
| Dilution | WB~~1:1000 |
| Target/Specificity | This CTDSP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 96-130 amino acids from the Central region of human CTDSP1. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CTDSP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTDSP1 |
|---|---|
| Synonyms | NIF3, NLIIF, SCP1 |
| Function | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. |
| Cellular Location | Nucleus. Note=Colocalizes with RNA polymerase II |
| Tissue Location | Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta |
Provided below are standard protocols that you may find useful for product applications.
Background
Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
References
Marquet S.,et al.Mamm. Genome 11:755-762(2000).
Yeo M.,et al.J. Biol. Chem. 278:26078-26085(2003).
Li W.B.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Yeo M.,et al.Science 307:596-600(2005).
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