|Calculated MW||H=31;M=32 KDa|
|Antigen Region||87-121 aa|
|Other Names||Deoxyribonuclease-1, Deoxyribonuclease I, DNase I, Dornase alfa, DNASE1, DNL1, DRNI|
|Target/Specificity||This DNASE1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 87-121 amino acids from the Central region of human DNASE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DNASE1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity).|
|Cellular Location||Secreted. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope|
|Tissue Location||Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva|
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Provided below are standard protocols that you may find useful for product applications.
Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity).
Shak S.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:9188-9192(1990).
Yasuda T.,et al.Ann. Hum. Genet. 59:1-15(1995).
Oliveri M.,et al.Eur. J. Immunol. 31:743-751(2001).
Kominato Y.,et al.FEBS J. 273:3094-3105(2006).
Martin J.,et al.Nature 432:988-994(2004).
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