|Calculated MW||H=212;M=212 KDa|
|Antigen Region||1812-1846 aa|
|Other Names||Dedicator of cytokinesis protein 2, DOCK2, KIAA0209|
|Target/Specificity||This DOCK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1812-1846 amino acids from the C-terminal region of human DOCK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DOCK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.|
|Cellular Location||Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin|
|Tissue Location||Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon|
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Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
Nagase T.,et al.DNA Res. 3:321-329(1996).
Nishihara H.,et al.Biochim. Biophys. Acta 1452:179-187(1999).
Nishihara H.,et al.Blood 100:3968-3974(2002).
Nishihara H.,et al.Biochem. Biophys. Res. Commun. 296:716-720(2002).
Cote J.-F.,et al.J. Cell Sci. 115:4901-4913(2002).
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