|Application ||WB, FC|
|Calculated MW||H=19;M=18 KDa|
|Antigen Region||137-165 aa|
|Other Names||Proepiregulin, Epiregulin, EPR, EREG|
|Target/Specificity||This EREG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-165 amino acids from the C-terminal region of human EREG.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EREG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).|
|Cellular Location||Epiregulin: Secreted, extracellular space|
|Tissue Location||In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon|
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Provided below are standard protocols that you may find useful for product applications.
EREG is a member of the epidermal growth factor family. EREG can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors.
Ben-Ami, I., et al. Hum. Reprod. 24(1):176-184(2009)
Cho, M.C., et al. Biochem. Biophys. Res. Commun. 377(3):832-837(2008)
Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008)
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