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(Mouse) Sox17 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF |
|---|---|
| Primary Accession | Q61473 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | M=45,31;H=44;R=45 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 20671 |
|---|---|
| Antigen Region | 353-387 aa |
| Other Names | Transcription factor SOX-17, Sox17, Sox-17 |
| Dilution | IF~~1:25 WB~~1:2000 IHC~~1:25 |
| Target/Specificity | This mouse Sox17 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 353-387 amino acids from the C-terminal region of mouse Sox17. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (Mouse) Sox17 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Sox17 |
|---|---|
| Synonyms | Sox-17 |
| Function | Acts as a transcription regulator that binds target promoter DNA and bends the DNA (PubMed:8636240, PubMed:24153254, PubMed:19328208). Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3' (PubMed:8636240). Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development (PubMed:11973269, PubMed:17655922, PubMed:24153254). Required for normal development of the definitive gut endoderm (PubMed:11973269). Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries (PubMed:24153254). Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18 (PubMed:16895970). Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis (PubMed:17655922). Probable transcriptional activator in the premeiotic germ cells. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:20802155, ECO:0000269|PubMed:24153254, ECO:0000269|PubMed:8636240} |
| Tissue Location | Detected in lung and testis (PubMed:8636240). Detected in endothelial cells around small and large arteries in newborns and adults, but is barely detectable in veins (at protein level) (PubMed:24153254). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells. Isoform 2 (T-SOX17) shows no DNA-binding activity.
References
Kanai Y.,et al.J. Cell Biol. 133:667-681(1996).
Carninci P.,et al.Science 309:1559-1563(2005).
Layfield R.,et al.Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases.
Kanai-Azuma M.,et al.Development 129:2367-2379(2002).
Kim I.,et al.Cell 130:470-483(2007).
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