|Application ||WB, IHC-P|
|Calculated MW||H=16;M=16 KDa|
|Antigen Region||31-65 aa|
|Other Names||Vesicle-associated membrane protein 4, VAMP-4, VAMP4|
|Target/Specificity||This VAMP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-65 amino acids from the Central region of human VAMP4.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VAMP4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles|
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