|Calculated MW||H=16;M=16;R=16 KDa|
|Antigen Region||102-136 aa|
|Other Names||Cellular retinoic acid-binding protein 2, Cellular retinoic acid-binding protein II, CRABP-II, CRABP2|
|Target/Specificity||This CRABP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-136 amino acids from the C-terminal region of human CRABP2.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CRABP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.|
|Cellular Location||Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus|
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A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The inducibility of the CRABP2 gene suggests that this isoform is important in retinoic acid-mediated regulation of human skin growth and differentiation. It has been postulated that the CRABP2 gene is transcriptionally regulated by a newly synthesized regulatory protein. [provided by RefSeq].
Sola, R., et al. Atherosclerosis 211(2):630-637(2010) Manolescu, D.C., et al. Pediatr. Res. 67(6):598-602(2010) Calmon, M.F., et al. Neoplasia 11(12):1329-1339(2009) Corlazzoli, F., et al. PLoS ONE 4 (1), E4305 (2009) : Gupta, A., et al. Exp. Cell Res. 314(20):3663-3668(2008)
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