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MBL2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF, WB |
|---|---|
| Primary Accession | P11226 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=26 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 4153 |
|---|---|
| Antigen Region | 188-222 aa |
| Other Names | Mannose-binding protein C, MBP-C, Collectin-1, MBP1, Mannan-binding protein, Mannose-binding lectin, MBL2, COLEC1, MBL |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 |
| Target/Specificity | This MBL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-222 amino acids from the C-terminal region of human MBL2. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MBL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MBL2 (HGNC:6922) |
|---|---|
| Synonyms | COLEC1, MBL |
| Function | Calcium-dependent lectin involved in innate immune defense (PubMed:35102342). Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342). |
| Cellular Location | Secreted. |
| Tissue Location | Plasma protein produced mainly in the liver. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases.
References
Auriti, C., et al. Hum. Immunol. 71(11):1084-1088(2010)
Fraser, D.A., et al. J. Immunol. 185(7):3932-3939(2010)
de Wit, E., et al. Mamm. Genome (2010) In press :
Filho, R.M., et al. Viral Immunol. 23(4):449-453(2010)
Hu, Y., et al. Viral Immunol. 23(4):443-447(2010)
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