|Calculated MW||H=24,29;M=24;R=24 KDa|
|Antigen Region||88-117 aa|
|Other Names||Receptor-binding cancer antigen expressed on SiSo cells, Cancer-associated surface antigen RCAS1, Estrogen receptor-binding fragment-associated gene 9 protein, EBAG9, RCAS1|
|Target/Specificity||This EBAG9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human EBAG9.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EBAG9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases.|
|Cellular Location||Golgi apparatus membrane; Single-pass type III membrane protein. Note=According to PubMed:10426319, it also exists as a soluble form which has the same biological activities. The existence of such soluble form is however uncertain|
|Tissue Location||Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs|
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Provided below are standard protocols that you may find useful for product applications.
This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene.
Wolf, J., et al. FASEB J. 24(10):4000-4019(2010)
Sonoda, K., et al. Exp. Cell Res. 316(11):1795-1803(2010)
Ali-Fehmi, R., et al. Cancer Biomark 6(1):33-48(2010)
Yang, Y.C., et al. Zhonghua Wai Ke Za Zhi 47(13):999-1001(2009)
Adamek, D., et al. Folia Neuropathol 47(3):240-246(2009)
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