|Calculated MW||H=48,41,38,35,43;M=48 KDa|
|Antigen Region||332-361 aa|
|Other Names||Squalene synthase, SQS, SS, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase, FDFT1|
|Target/Specificity||This FDFT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-361 amino acids from the C-terminal region of human FDFT1.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FDFT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.
Chalasani, N., et al. Gastroenterology 139(5):1567-1576(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kovanen, L., et al. Alcohol Alcohol. 45(4):303-311(2010)
Lipkin, S.M., et al. Cancer Prev Res (Phila) 3(5):597-603(2010)
Sjoholm, L.K., et al. J Circadian Rhythms 8, 1 (2010) :
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