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HPN Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - HPN Antibody (Center) AW5568-U200
    All lanes : Anti-HPN Antibody (Center) at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: MCF-7 whole cell lysate Lane 3: SW620 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 45 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P05981
Other Accession Q5R5E8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW H=45;M=47,45;R=45 KDa
Additional Information
Gene ID 3249
Antigen Region 153-188 aa
Other Names Serine protease hepsin, Transmembrane protease serine 1, Serine protease hepsin non-catalytic chain, Serine protease hepsin catalytic chain, HPN, TMPRSS1
Dilution WB~~1:2000
Target/Specificity This HPN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 153-188 amino acids from the Central region of human HPN.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHPN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HPN
Synonyms TMPRSS1
Function Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).
Cellular Location Cell membrane; Single-pass type II membrane protein Apical cell membrane; Single-pass type II membrane protein
Tissue Location Detected in liver and kidney.
Research Areas
Citations (0)

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Background

Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2.

References

Leytus S.P.,et al.Biochemistry 27:1067-1074(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Tsuji A.,et al.J. Biol. Chem. 266:16948-16953(1991).
Torres-Rosado A.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:7181-7185(1993).
Chen R.,et al.J. Proteome Res. 8:651-661(2009).

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$ 325.00
$ 110.00
Cat# AW5568-U200
Size:
Quantity:
(40 western blots)
Availability: In Stock
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