|Calculated MW||H=45;M=47,45;R=45 KDa|
|Antigen Region||153-188 aa|
|Other Names||Serine protease hepsin, Transmembrane protease serine 1, Serine protease hepsin non-catalytic chain, Serine protease hepsin catalytic chain, HPN, TMPRSS1|
|Target/Specificity||This HPN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 153-188 amino acids from the Central region of human HPN.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HPN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).|
|Cellular Location||Cell membrane; Single-pass type II membrane protein Apical cell membrane; Single-pass type II membrane protein|
|Tissue Location||Detected in liver and kidney.|
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Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2.
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Ota T.,et al.Nat. Genet. 36:40-45(2004).
Tsuji A.,et al.J. Biol. Chem. 266:16948-16953(1991).
Torres-Rosado A.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:7181-7185(1993).
Chen R.,et al.J. Proteome Res. 8:651-661(2009).
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