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HFE2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - HFE2 Antibody (Center) AW5578-U200
    All lanes : Anti-HFE2 Antibody (Center) at 1:1000 dilution Lane 1: human heart lysate Lane 2: human skeletal muscle lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 45 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • IHC-P - HFE2 Antibody (Center) AW5578-U200
    HFE2 Antibody (Center) (Cat. #AW5578) IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HFE2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6ZVN8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW H=45,34;M=45;R=45 KDa
Additional Information
Gene ID 148738
Antigen Region 134-162 aa
Other Names Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C, HFE2, HJV, RGMC
Dilution WB~~1:1000
Target/Specificity This HFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-162 amino acids from the Central region of human HFE2.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHFE2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HFE2
Synonyms HJV, RGMC
Function Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Note=Also released in the extracellular space.
Tissue Location Adult and fetal liver, heart, and skeletal muscle.
Research Areas
Citations (0)

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HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin.


Zhu, X., et al. Genet. Epidemiol. 34(2):171-187(2010)
Barton, J.C., et al. Am. J. Hematol. 84(11):710-714(2009)
Zhang, A.S., et al. J. Biol. Chem. 284(34):22580-22589(2009)

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$ 325.00
$ 110.00
Cat# AW5578-U200
(40 western blots)
Availability: In Stock
Bulk Size
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