|Application ||IHC-P, WB|
|Other Accession||A7MAZ4, Q5ZMS1|
|Calculated MW||H=34,37;M=29,34,35,24 KDa|
|Antigen Region||151-178 aa|
|Other Names||Transcription initiation factor TFIID subunit 8, Protein taube nuss, TBP-associated factor 43 kDa, TBP-associated factor 8, Transcription initiation factor TFIID 43 kDa subunit, TAFII-43, TAFII43, hTAFII43, TAF8, TAFII43, TBN|
|Target/Specificity||This TAF8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-178 amino acids from the Central region of human TAF8.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAF8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq].
Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
Soutoglou, E., et al. Mol. Cell. Biol. 25(10):4092-4104(2005)
Guermah, M., et al. Mol. Cell 12(4):991-1001(2003)
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