|Application ||IF, WB|
|Calculated MW||H=68, 69, 61, 63;M=68 KDa|
|Antigen Region||619-654 aa|
|Other Names||RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein, EWSR1, EWS|
|Target/Specificity||This EWSR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 619-654 amino acids from the C-terminal region of human EWSR1.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EWSR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.|
|Cellular Location||Nucleus. Cytoplasm. Cell membrane. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation|
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Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
Delattre O.,et al.Nature 359:162-165(1992).
Plougastel B.,et al.Genomics 18:609-615(1993).
Zucman-Rossi J.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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