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EWSR1 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IF, WB |
|---|---|
| Primary Accession | Q01844 |
| Other Accession | Q61545 |
| Reactivity | Human, Mouse |
| Predicted | Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=68, 69, 61, 63;M=68 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 2130 |
|---|---|
| Antigen Region | 619-654 aa |
| Other Names | RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein, EWSR1, EWS |
| Dilution | IF~~1:25 WB~~1:2000 |
| Target/Specificity | This EWSR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 619-654 amino acids from the C-terminal region of human EWSR1. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EWSR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EWSR1 |
|---|---|
| Synonyms | EWS |
| Function | Might normally function as a transcriptional repressor. EWS- fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Cellular Location | Nucleus. Cytoplasm. Cell membrane. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation |
| Tissue Location | Ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
References
Delattre O.,et al.Nature 359:162-165(1992).
Plougastel B.,et al.Genomics 18:609-615(1993).
Zucman-Rossi J.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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