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Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q99436 |
| Other Accession | Q2TBP0, P70195, Q9JHW0 |
| Reactivity | Human, Mouse |
| Predicted | Human, Dog, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=30;M=30;R=30 KDa |
| Gene ID | 5695 |
|---|---|
| Antigen Region | 180-211 aa |
| Other Names | Proteasome subunit beta type-7, Macropain chain Z, Multicatalytic endopeptidase complex chain Z, Proteasome subunit Z, PSMB7, Z |
| Dilution | IHC~~1:25 WB~~1:8000 |
| Target/Specificity | This PSMB7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 180-211 amino acids from the Central region of human PSMB7. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PSMB7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PSMB7 |
|---|---|
| Synonyms | Z |
| Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity. |
| Cellular Location | Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00809, ECO:0000269|PubMed:18549262}. Nucleus |
| Tissue Location | Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity.
References
Hisamatsu H.,et al.J. Exp. Med. 183:1807-1816(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.
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