SAMHD1 Antibody (Center)
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB |
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Primary Accession | Q9Y3Z3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | H=72,69,64,68 KDa |
Isotype | Rabbit Ig |
Antigen Source | HUMAN |
Gene ID | 25939 |
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Antigen Region | 204-230 aa |
Other Names | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, dNTPase, 315-, Dendritic cell-derived IFNG-induced protein, DCIP, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1, SAMHD1, MOP5 |
Dilution | WB~~0.25 |
Target/Specificity | This SAMHD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-230 amino acids from the Central region of human SAMHD1. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SAMHD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SAMHD1 |
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Synonyms | MOP5 |
Function | Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling. |
Cellular Location | Nucleus |
Tissue Location | Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus |

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Background
This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq].
References
Tomkova, H., et al. Eur J Dermatol 20(3):411-413(2010)
Dale, R.C., et al. Am. J. Med. Genet. A 152A (4), 938-942 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Rice, G.I., et al. Nat. Genet. 41(7):829-832(2009)
Liao, W., et al. Proteomics 8(13):2640-2650(2008)

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