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Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9Y3Z3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=72,69,64,68 KDa |
| Gene ID | 25939 |
|---|---|
| Antigen Region | 204-230 aa |
| Other Names | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, dNTPase, 315-, Dendritic cell-derived IFNG-induced protein, DCIP, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1, SAMHD1, MOP5 |
| Dilution | WB~~0.25 |
| Target/Specificity | This SAMHD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-230 amino acids from the Central region of human SAMHD1. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SAMHD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SAMHD1 |
|---|---|
| Synonyms | MOP5 |
| Function | Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling. |
| Cellular Location | Nucleus |
| Tissue Location | Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq].
References
Tomkova, H., et al. Eur J Dermatol 20(3):411-413(2010)
Dale, R.C., et al. Am. J. Med. Genet. A 152A (4), 938-942 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Rice, G.I., et al. Nat. Genet. 41(7):829-832(2009)
Liao, W., et al. Proteomics 8(13):2640-2650(2008)
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