|Other Accession||Q01059, Q63270|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||H=98;M=98;R=98 KDa|
|Antigen Region||124-155 aa|
|Other Names||Cytoplasmic aconitate hydratase, Aconitase, 18.104.22.168, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1, ACO1, IREB1|
|Target/Specificity||This ACO1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 124-155 amino acids from human ACO1.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACO1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.|
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Provided below are standard protocols that you may find useful for product applications.
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
Hirling H.,et al.Nucleic Acids Res. 20:33-39(1992).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Rouault T.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7958-7962(1990).
Hentze M.W.,et al.Nucleic Acids Res. 19:1739-1740(1991).
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