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DANRE neurog1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - DANRE neurog1 Antibody (Center) Azb10027b
    DANRE neurog1 Antibody (Center) (Cat. #Azb10027b) western blot analysis in zebra fish brain tissue lysates (35ug/lane).This demonstrates the DANRE neurog1 antibody detected the DANRE neurog1 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O42606
Reactivity Zebrafish
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 22911 Da
Antigen Region 112-138 aa
Additional Information
Gene ID 30239
Other Names Neurogenin-1, NGN-1, Neurogenic differentiation factor 3, NeuroD3, Neurogenin-related protein 1, neurog1, neurod3, ngn1, ngr1
Target/Specificity This DANRE neurog1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-138 amino acids from the Central region of DANRE neurog1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDANRE neurog1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name neurog1
Synonyms neurod3, ngn1, ngr1
Function Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon- Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specification of dopaminergic progenitor cells. May be involved in maintaining rhombomere boundaries in the hindbrain.
Cellular Location Nucleus.
Tissue Location Embryonic nervous system. Expressed transiently in neurogenic placodes prior to delamination and formation of cranial ganglia. Expressed early (6-somite stage) in Rohon-Beard spinal sensory neurons and later in neural crest- derived dorsal root ganglion neurons. At 24 hours post- fertilization (hpf), expressed in specific regions of the brain and spinal cord. In hindbrain, expressed in presumptive neuroblasts adjacent to the rhombomere boundaries. In basal forebrain, expressed in dopaminergic progenitor cells
Research Areas
Citations (0)

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Background

Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specification of dopaminergic progenitor cells. May be involved in maintaining rhombomere boundaries in the hindbrain.

References

Blader P., et al. Development 124:4557-4569(1997).
Kim C.-H., et al. Neurosci. Lett. 239:113-116(1997).
Korzh V., et al. Dev. Dyn. 213:92-104(1998).
Thisse B., et al. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
Cornell R.A., et al. Development 129:2639-2648(2002).

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Cat# Azb10027b
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(40 western blots)
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